PREPRINTS
Kumar Bharathkar, S., Miller, M.J., and Stadtmueller, B.M. Engineered Secretory Immunoglobulin A provides insights on antibody-based effector mechanisms targeting Clostridiodes difficile. bioRxiv 2023.11.08.566291; doi: https://doi.org/10.1101/2023.11.08.566291
Kumar Bharathkar, S. and Stadtmueller, B.M. Structural and biochemical requirements for secretory component interactions with dimeric Immunoglobulin A. bioRxiv 2023.11.09.566401; doi: https://doi.org/10.1101/2023.11.09.566401
Gregory P. Donaldson, Gabriella L. Reis, Marwa Saad, Izabela Mamede, Guo Chen, Nicole L. DelGaudio, Dayu Zhang, Begüm Aydin, Caroline E. Harrer, Tiago BR Castro, Sergei Grivennikov, Bernardo S. Reis, Beth M. Stadtmueller, Gabriel D. Victora, Daniel Mucida. Suppression of epithelial proliferation and tumorigenesis by immunoglobulin A. bioRxiv 2023.10.06.561290; doi: https://doi.org/10.1101/2023.10.06.561290
Hockenberry A, Radiom M, Arnoldini M, Turgay Y, Dunne M, Adamcik J, Stadtmueller BM, Mezzenga R, Ackermann M, Slack E. Nanoscale clustering by O-antigen-Secretory Immunoglobulin-A binding limits outer membrane diffusion by encaging individual Salmonella cells. bioRxiv. 2023 Jul 14:2023.07.13.548943. https://doi.org/10.1101/2023.07.13.548943
PUBLICATIONS
Lyu, M., Malyutin, A.G., and Stadtmueller, B.M. The structure of the teleost Immunoglobulin M core provides insights on polymeric antibody evolution, assembly, and function. Nat. Commun. 14, 7583 (2023) https://doi.org/10.1038/s41467-023-43240-z
Liu, Q., and Stadtmueller, B.M. SIgA structures bound to Streptococcus pyogenes M4 and human CD89 provide insights into host-pathogen interactions. Nat. Commun. 14, 6726 (2023). https://doi.org/10.1038/s41467-023-42469-y
Hockenberry A*, Slack E*, Stadtmueller BM*. License to Clump: Secretory IgA Structure-Function Relationships Across Scales. Annu Rev Microbiol. 2023 Sep 15;77:645-668. doi: 10.1146/annurev-micro-032521-041803. PMID: 37713459. https://www.annualreviews.org/doi/abs/10.1146/annurev-micro-032521-041803
Diefenbacher, M., Tan, T.J.C., Bauer, D.L.V., Stadtmueller, B.M., Wu, N.C., Brooke, C.B. Interactions between Influenza A Virus Nucleoprotein and Gene Segment Untranslated Regions Facilitate Selective Modulation of Viral Gene Expression. J Virol 96, e00205-22 (2022). https://doi.org/10.1128/jvi.00205-22
Tan, T.J.C., Yuan, M., Kuzelka, K., Padron, G.C., Beal, J.R., Chen, X., Wang, J., Rivera-Cardona, J., Zhu, X., Stadtmueller, B.M., Brooke, C.B., Wilson, I.A., Wu, N.C. Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain. Nat. Commun. 12, 3815 (2021). https://doi.org/10.1038/s41467-021-24123-7
Diard, M., Bakkeren, E., Lentsch, V., Rocker, A., Bekele, N.A., Hoces, D., Aslani, S., Arnoldini, M., Bohi, F., Schumann-Moor, K., Adamcik, J., Piccoli, L., Lanzavecchia, A., Stadtmueller, B.M., Donohue, N., van der Woude, M.W., Hockenberry, A., Viollier, P.H., Falquet, L., Wuthrich, D., Bonfiglio, F., Loverdo, C., Egli, A., Zandomeneghi, G., Mezzenga, R., Holst, O., Meier, B.H., Hardt, W.D., Slack, E. A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants. Nat. Microbiol. 6, 830-841 (2021). https://doi.org/10.1038/s41564-021-00911-1
Bharathkar, S.K., Parker, B.W., Malyutin, A.G., Haloi, N., Huey-Tubman, K.E., Tajkhorshid, E., Stadtmueller, B.M. The structures of secretory and dimeric immunoglobulin A. eLife 9, e56098 (2020). https://doi.org/10.7554/eLife.56098
Stadtmueller, B.M., Bridges, M.D., Dam, K.M., Lerch, M.T., Huey-Tubman, K.E., Hubbell, W.L., Bjorkman, P.J. DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions. Immunity 49, 235-246 (2018). https://doi.org/10.1016/j.immuni.2018.06.017
Stadtmueller, B.M., Yang, Z., Huey-Tubman, K.E., Roberts-Mataric, H., Hubbell, W.L., Bjorkman, P.J. Biophysical and Biochemical Characterization of Avian Secretory Component Provides Structural Insights into the Evolution of the Polymeric Ig Receptor. J. Immunol. 197, 1408-1414 (2016). https://doi.org/10.4049/jimmunol.1600463
Stadtmueller, B.M., Huey-Tubman, K.E., López, C.J., Yang, Z., Hubbell, W.L., Bjorkman P.J. The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins. eLife 5, e10640 (2016). https://doi.org/10.7554/eLife.10640
Stadtmueller, B.M., Kish-Trier E., Ferrell K., Petersen C.N., Robinson H., Myszka D.G., Eckert D.M., Formosa T, Hill C.P. Structure of a proteasome Pba1-Pba2 complex: implications for proteasome assembly, activation, and biological function. J. Biol. Chem. 287 (44), 37371-82 (2012) https://doi.org/10.1074/jbc.M112.367003
Stadtmueller, B.M. and Hill C.P. Proteasome activators. Mol. Cell 44 (1), 8-19 (2011). https://doi.org/10.1016/j.molcel.2010.12.020
Stadtmueller, B.M., Ferrell K., Whitby F.G., Heroux A., Robinson H., Myszka D.G., Hill C.P. Structural models for interactions between the 20S proteasome and its PAN/19S activators. J. Biol. Chem. 285 (1), 13-17 (2010). https://doi.org/10.1074/jbc.C109.070425
Phillips J.D., Whitby F.G., Stadtmueller, B.M., Edwards C.Q., Hill C.P., Kushner, J.P. Two novel uroporphyrinogen decarboxylase (URO-D) mutations causing hepatoerythropoietic porphyria (HEP). Transl. Res. 149 (2), 85-91 (2007). https://doi.org/10.1016/j.trsl.2006.08.006