https://www.stadtmuellerlab.org/lab-members daily 0.75 2026-03-18 https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/1585162488160-AUES17BA6X74ZK1UUFZU/Heather.JPG Lab Members https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/5f9b9ed4-2a89-43b4-8b9f-00d785f3a20b/IMG_7316.JPG Lab Members https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/4a90d830-e517-44fd-a05f-17559621caeb/Asta+picture.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/1597974750846-MDQSH555AFGA5PRX26J3/IMG_0462.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/1623703797101-7PGFHQQ1ZVPMCLOGFYNW/IMG_5583.JPG Lab Members https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/1624039763994-DTNCE4RL6CUJ1OSAPB50/Image+from+iOS.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/1625589562952-N0US0MC31VUI9T7Y1KCR/tempImageTn52yD.gif Lab 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https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/1660611767529-RR6PDVZN0Q4QLVOI32FR/UW%2BMadison%2Bgroup%2Bpicture%2Bbright%2Bcopy.jpg Home https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/3e0ebf99-191b-4a84-a9fc-b1d37d717d8d/Stadtmueller_Lab-220930-FZ-007.JPG Home https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/1688534918507-3CEITLZF32348CP0MM8V/tempImagevy7ebY.jpg Home https://www.stadtmuellerlab.org/research-1 daily 0.75 2023-01-26 https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/9d02ae9f-131a-41c2-87c0-68afcb0fae1e/Stadtmueller_Lab-220930-FZ-077.JPG Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/fc1f2a08-d9f5-4324-a741-f38fba1f06c7/Stadtmueller_Lab-220930-FZ-020.JPG Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/d9c2d8f8-2627-4084-86fd-23c2d94c4c42/Stadtmueller_Lab-220930-FZ-009.JPG Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/1237da54-4a63-401f-879f-a519277188d8/Stadtmueller_Lab-220930-FZ-059.JPG Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/1603473870316-2RYT5VQJ3O09337T6SAQ/Figure_7.png Research - To the right, Model for the formation, transport and function of Secretory IgA based on cryo-EM structures. Schematic summary depicting the unliganded polymeric Ig receptor (pIgR; pdb code 5D4K) bound to basolateral surface of an epithelial cell in its closed conformation and recognizing bent, dimeric (d) IgA (pdb code 7JG1) from the lamina propria. The pIgR binding to dIgA triggers a conformation change that repositions its domains to facilitate numerous stabilizing contacts with dIgA. The dIgA-pIgR complex (PDB code 7JG2) transcytoses to the apical membrane where the pIgR is proteolytically cleaved, releasing Secretory (S) IgA into the mucosa. In the mucosa, SIgA Fabs (shown in plausible, modeled positions) are directed toward the concave side of the antibody ‘looking’ for potential antigens while its Fc receptor binding regions are exposed on the convex side and accessible to potential host or microbial receptors. The pIgR ectodomain (SC) domains are also partially exposed; the D2 domain is almost completely accessible, protruding out of the SIgA where it may bind host and bacterial factors. Upon encountering antigen, SIgA Fabs bind, promoting antigen coating, agglutination or enchained growth (https://elifesciences.org/articles/56098 ). https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/e0672501-d50a-4a86-9f98-286a00a4a52e/Stadtmueller_Lab-220930-FZ-039.JPG Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/6446212d-6387-4140-a0a9-18b6aef69194/Stadtmueller_Lab-220930-FZ-011.JPG Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/d2718ba5-410b-4c19-8160-2afa56935465/Stadtmueller_Lab-220930-FZ-053.JPG Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/03e7afb0-8d41-4faa-ac0d-9ce22b3fba32/Stadtmueller_Lab-220930-FZ-015.JPG Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/b16e2dea-0fee-4590-a5c4-e7f1fccaf311/Stadtmueller_Lab-220930-FZ-001.JPG Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.stadtmuellerlab.org/contact daily 0.75 2026-03-18 https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/2d68c25d-32a1-4d22-a0fc-529772b99c09/Rogr+Adams+with+sign+_1.jpg Contact - Our Main Lab https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/307619fe-6c48-4bd9-a1c7-6afa55491c18/DarwinsPlayground.jpg Contact - Find our collaborative lab in the Carl R. Woese Institute for Genomic Biology Theme: "Mining Microbial Genomes" Lab: 3200 IGB Beth's office: 3107 IGB 1206 W Gregory Dr, Urbana, IL 61801 https://www.stadtmuellerlab.org/new-page-1 daily 0.75 2026-03-18 https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/cc788d35-7061-41f4-93da-401c7c635561/SPR_IGB.jpg Resources - Surface Plasmon Resonance (SPR) Lab at the Carl R. Woese Institute for Genomic Biology The Stadtmueller lab houses a Bruker “Sierra SPR-32-Pro” high-throughput biosensor. The SPR-32 allows label-free analysis of molecular interactions and can be used to measure the affinity, kinetics or thermodynamics of binding between biological and/or synthetic molecules. Please contact: Sarah Leonard (spleonar@illinois.edu) Beth Stadtmueller (bethms@illinois.edu) https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/7ead2c17-5f2a-4090-87d6-e65fecdd814e/SEC_MALS_IGB.jpg Resources - SEC-MALS at IGB The Stadtmueller lab manages a system to conduct Size Exclusion Chromatography with in-line Multi-Angle Light Scattering (SEC-MALS), which facilitates protein molecular weight determination. Please contact: Yujia Ji (yujiaji3@illinois.edu) Beth Stadtmueller (bethms@illinois.edu) https://www.stadtmuellerlab.org/the-best-times daily 0.75 2025-08-30 https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/73ed82e2-27da-4246-b1ca-1af2da2f1713/Screenshot+2025-08-30+at+11.10.46+AM.png The BeSt Times - August 2025 Beth is promoted to Associate Professor with tenure and is named the 2025 Helen Corley Petit Scholar. https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/c6e2f6c7-7560-44a0-b50f-82a5cdd4b90a/EPI+Retreat+2025.jpg The BeSt Times - August 2025 Stadtmueller, Mehta, Wu and van der Donk Labs dressed as duck hunters for the 2025 EPI Retreat in Estes Park, CO hosted by Jenn Guthmiller and her lab! https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/29144b21-7235-4165-9136-a9748361a1f0/IMG_1487+copy.jpg The BeSt Times - Spring 2025 Congrats to Mengfan (Iris) Lyu who successfully defended her dissertation on fish IgM structure and engineering! https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/2c646d3f-9d5f-4ad0-a435-5f9b869582f4/Screenshot+2023-11-13+at+1.45.37+PM.png The BeSt Times - November 2023 Congrats Dr. Sonya Kumar Bharathkar! The first PhD student to join the lab successfully defends epic dissertation research on the structures, assembly and engineering of SIgA. https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/58a64715-c923-4b33-853f-289bc188e097/Screenshot+2023-11-13+at+1.40.20+PM.png The BeSt Times - October 2023 Heather’s paper is published in Nature Communications! Read the story here: https://www.nature.com/articles/s41467-023-42469-y https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/6179182d-a756-4923-8471-a209c3b95a62/Screenshot+2023-11-13+at+1.33.58+PM.png The BeSt Times - October 2023 Congrats Dr. Qianqiao (Heather) Liu! The first PhD graduate from the Stadtmueller Lab. We wish you the best of adventures in the Sharaf Lab at Stanford! https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/96dcb974-c966-4144-9e1c-5ed5d0f7f8f5/Screenshot+2023-11-13+at+2.27.26+PM.png The BeSt Times - September 2023 Beth and Heather give the NIH Common Fund Transformative High Resolution CryoEM Webinar. Click on the image to learn more and watch the seminar! https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/f5d3d18e-69ca-4e75-b65a-54135c5fc714/tempImageL29g7O.jpg The BeSt Times - June 2023 The Stadtmueller, Mehta, Wu, Guthmiller (CU Anschutz), and van der Donk labs gathered to share research progress on influenza-related projects. https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/75c08144-cb0d-43d4-81e9-42a3f5db4c26/IMG_8637.jpg The BeSt Times - May 2023 Iris is awarded the Lowell P. Hager Fellowship in Biochemistry! https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/7376bcd5-a7ad-48ec-9b93-3fa4fc46ae9f/Asta_Surf.jpg The BeSt Times - May 2023 Congrats to our outstanding undergraduate, Asta (and graduate student mentor, Rebecca), for being awarded the Spudich Summer Undergraduate Research Fellowship!!! https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/e4a1ab91-6bc9-4ca9-b994-18e4faf6f2c6/IMG_8675+%282%29.JPG The BeSt Times - March 2023 The Stadtmueller Lab attends the West Coast Structural Biology Workshop in Pacific Grove, CA. Great talks and posters by Sonya, Iris and Heather! https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/82260269-d9b8-4e59-8da1-6871cec9bbcb/Group+photo+in+lab.JPG The BeSt Times - January 26th, 2023 Stadtmueller, Mehta, Wu, Guthmiller and van der Donk Labs awarded $9.5 Million from HHMI to investigate and engineer antibody responses to influenza. HHMI News Release MCB News Release https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/fcd41a9e-e37d-4644-9397-384a60c9d01b/ICMI+group.jpg The BeSt Times - July 2022 Beth, Sonya, and Iris traveled to Seattle to present work at the 20th International Congress of Mucosal Immunology. https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/b05bcd96-e853-4db0-9065-c0763aea5125/UW+MAdison+Group+Inside.jpg The BeSt Times - June 2022 Beth and the grad students attend the 42nd Steenbock Symposium held at UW-Madison. https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/c0b26519-dcb8-42e7-9391-eaf7905a097a/IMG_5170.jpeg The BeSt Times - May 2022 Heather was awarded the Dr. Michael A. Recny Graduate Fellowship for the upcoming academic year! https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/599e43e1-02fe-491c-a8c6-7e5e620dae7b/Beth_3rd_year_review.jpg The BeSt Times - December 2021 Beth gives her 3rd-year review seminar detailing a lot of hard work by all lab members! https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/7dcdfeee-5a63-4091-9904-dc817e2d5542/IMG_3344.JPG The BeSt Times - November 2021 Stadtmueller Lab funding from our new NIAID R01 begins! https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/74791532-efa5-49e3-84c7-8d19f5af491e/Homer+Lake+group+.jpg The BeSt Times - June 2021 The Stadtmueller and Kieffer Labs spend the day at Homer Lake! https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/a697b525-d0c1-4b87-8440-5fd5361e5144/Iris_and_Rebecca+copy.jpg The BeSt Times - April 2021 Iris and Rebecca passed their prelim exams this month and are now officially PhD candidates. https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/1623705067372-X7V083ZC8RU5QI6LB0CF/6D97DE29-87BD-4868-8581-B58D507AC1EF.jpeg The BeSt Times - December 2020 Stadtmueller Lab featured on the MCB website! https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/1610660823089-D6KYKD13E1JU1Y1XUSVH/IMG_5517.jpg The BeSt Times - November 2020 Sonya received the Lowell P. Hager Fellowship in Biochemistry! Great job Sonya! https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/1607554256915-KS2HU5XWCII22GXEM83A/elife-56098-fig2-v2.jpg The BeSt Times - October 2020 The BeSt Lab’s first paper is out! Congrats to Sonya, Ben, and the entire lab for an extraordinary effort during extraordinary times! https://images.squarespace-cdn.com/content/v1/5e386d11335e5a7e1f7e6242/1604086913139-51RWAYZM1VE113IE67QV/494E6909-8C91-45C3-B6C4-A7F58C7E8B59.jpg The BeSt Times - September 2020 Congrats to Sonya on passing her prelims!!